Tom CHEUNG 張曉東

Tom
CHEUNG
張曉東

PhD in Biochemistry
S H Ho Associate Professor of Life Science
Associate Professor
Director of HKUST-BGI Joint Research Center
Associate Director of Biosciences Central Research Facility
Research Interests
Aging
Muscle stem cells
Muscular dystrophy
Single particle / molecule / cell studies
Stem cell biology
Selected Publications
Liu, Ling; Cheung, Tom H.; Charville, Gregory W.; Hurgo, Bernadette Marie Ceniza; Leavitt, Tripp; Shih, Johnathan; Brunet, Anne; Rando, Thomas A., Chromatin Modifications as determinants of muscle stem cell quiescence and chronological aging, 2013, Link
Ip, Fanny; Ng, Yupong; Or, Terry Cho Tsun; Sun, Peiran; Fu, Guangmiao; Li, Jessica Y.H.; Ye, Wencai; Cheung, Tom H.; Ip, Nancy Y.Y., Anemoside A3 Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating T Helper 17 Cell Response, 2017, Link
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, I.C.W.; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Y.Y., IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline, 2016, Link
Wang, Gang; Zhu, Han; Situ, Chenghao; Han, Lifang; Yu, Youqian; Cheung, Tom H.; Liu, Kai; Wu, Zhenguo, p110α of PI3K is Necessary and Sufficient for Quiescence Exit in Adult Muscle Satellite Cells, 2018, Link
van der Wal, E.; Herrero-Hernandez, P.; Wan, Raymond; Broeders, M.; in 't Groen, S.L.M.; van Gestel, T.J.M.; van IJcken, W.F.J.; Cheung, Hiu Tung; van der Ploeg, A.T.; Schaaf, G.J.; Pijnappel, W.W.M.P., Large-Scale Expansion of Human iPSC-Derived Skeletal Muscle Cells for Disease Modeling and Cell-Based Therapeutic Strategies, 2018, Link
So, Wai Kin; Cheung, Tom, Molecular Regulation of Cellular Quiescence: A Perspective from Adult Stem Cells and Its Niches, 2018, Link
Liu, Ling; Charville, Gregory W.; Cheung, Tom H.; Yoo, Bryan; Santos, Pauline J.; Schroeder, Matthew; Rando, Thomas A., Impaired notch signaling leads to a decrease in p53 activity and mitotic catastrophe in aged muscle stem cells, 2018, Link
An, Yitai; Wang, Gang; Diao, Yarui; Long, Yanyang; Fu, Xinrong; Weng, Mingxi; Zhou, Liang; Sun, Kun; Cheung, Tom H.; Ip, Nancy Y.; Sun, Hao; Wang, Huating; Wu, Zhenguo, A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes, 2017, Link
Kong, Cihang; Pilger, Christian; Hachmeister, Henning; Wei, Xiaoming; Cheung, Tom H.; Lai, Cora S. W.; Huser, Thomas; Tsia, Kevin. K.; Wong, Kenneth K. Y., Compact fs Ytterbium Fiber Laser at 1010 nm for Biomedical Applications, 2017, Link
Zhou, Xiaopu; Ip, Nancy Yuk-Yu; Cheung, Tom; Liew, F.Y.; Chan, I.C.W.; Mak, D.S.Y.; Yuen, M.Y.F.; Hung, Kwok Wang; Fu, Kit Yu; Fu, Wing Yu, IL-33 modulates microglial innate immunity in an Alzheimer’s disease-like mouse model, 2016, Link
Mueller, Alisa A.; Van Velthoven, Cindy T.; Fukumoto, Kathryn D.; Cheung, Tom H.; Rando, Thomas A., Intronic Polyadenylation of PDGFRα in Resident Stem Cells Attenuates muscle Fibrosis, 2016, Link
Stunnenberg, Hendrik G.; The International Human Epigenome Consortium; Cheung, Tom H.; Hirst, Martin, The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery, 2016, Link
Song, Wenqian; Wang, Ran; Jiang, Weimin; Yin, Qi; Peng, Guangdun; Yang, Ruikai; Yu, Qing Cissy; Chen, Jianfeng; Li, Jingsong; Cheung, Hiu Tung; Jing, Naihe; Zeng, Yi Arial, Hormones Induce the Formation of Luminal-derived Basal Cells in the Mammary Gland, 2019, Link
Zhu, Han; Xiao, Fang; Wang, Gang; Wei, Xiuqing; Jiang, Lei; Chen, Yan; Zhu, Lin; Wang, Haixia; Diao, Yarui; Wang, Huating; Ip, Nancy Y Y; Cheung, Tom H.; Wu, Zhenguo, STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration, 2016, Link
Fu, Kit Yu; Hung, Kwok Wang; Yuen, Yat Fai; Zhou, Xiaopu; Mak, Deejay S.Y.; Chan, Chi Wai; Cheung, Tom H.; Zhang, Baorong; Fu, Wing Yu; Liew, Foo Y.; Ip, Nancy Y.Y., IL-33 Ameliorates Alzheimer’s Disease-like Pathology and Cognitive Decline, 2016, Link
Liu, Ling; Cheung, Tom Hiu Tung; Charville, Gregory William; Rando, Thomas A., Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting, 2015, Link
Charville, Gregory W.; Cheung, Tom H.; Yoo, Bryan; Santos, Pauline J.; Lee, Gordon K.; Shrager, Joseph B.; Rando, Thomas A., Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells, 2015, Link
Fu, Wing Yu; Fu, Kit Yu; Hung, Kwok Wang; Yuen, Matthew Ming Fai; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Liew, F.Y.; Cheung, Tom H.; Ip, Nancy Y.Y., IL-33 Modulates the Inflammatory Response in the Brains of Alzheimer’s disease mouse model, 2016, Link
Fu, Kit Yu; Hung, Kwok Wang; Yuen, M.Y.F.; Zhou, Xiaopu; Mak, D.S.Y.; Chan, I.C.W.; Cheung, Tom; Zhang, B; Fu, Wing Yu; Liew, F.Y.; Ip, Nancy Yuk-Yu, IL-33 ameliorates cognitive deficits and amyloid pathology in an Alzheimer’s disease-like mouse model, 2016, Link
Cheung, Tom Hiu Tung; Rando, Thomas A., Molecular regulation of stem cell quiescence, 2013, Link
Schweppe, RE; Cheung, Tom Hiu Tung; Ahn, NG, Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses, 2006, Link
Boutet, S.C.; Cheung, Tom Hiu Tung; Quach, N.L.; Liu, L.; Prescott, S.L.; Edalati, A.; Iori, K.; Rando, T.A., Alternative polyadenylation mediates microRNA regulation of muscle stem cell function, 2012, Link
Cheung, Tom Hiu Tung; Quach, N.L.; Charville, G.W.; Liu, L.; Park, L.; Edalati, A.; Yoo, B.; Hoang, P.; Rando, T.A., Maintenance of muscle stem-cell quiescence by microRNA-489, 2012, Link
Cheung, Tom Hiu Tung; Barthel, K.K.B.; Yin, L.K.; Liu, X., Identifying pattern-defined regulatory islands in mammalian genomes, 2007, Link
Luczak, E.D.; Barthel, K.K.B.; Stauffer, B.L.; Konhilas, J.P.; Cheung, Tom Hiu Tung; Leinwand, L.A., Remodeling the cardiac transcriptional landscape with diet, 2011, Link
Zhang, L.; Ding, L.; Cheung, Tom Hiu Tung; Dong, M.Q.; Chen, J.; Sewell, A.K.; Liu, X.; Yates III, J.R.; Han, M., Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2, 2007, Link
Bjornson, C.R.R.; Cheung, Tom Hiu Tung; Liu, L.; Tripathi, P.V.; Steeper, K.M.; Rando, T.A., Notch signaling is necessary to maintain quiescence in adult muscle stem cells, 2012, Link
Cheung, Tom Hiu Tung; Kwan, YL; Hamady, M.; Liu, X., Unraveling transcriptional control and cis-regulatory codes using the software suite GeneACT, 2006, Link
Resing, KA; Meyer-Arendt, K.; Mendoza, AM; Aveline-Wolf, LD; Jonscher, KR; Pierce, KG; Old, WM; Cheung, Tom Hiu Tung; Russell, S.; Wattawa, JL; Goehle, GR; Knight, RD; Ahn, NG, Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics, 2004, Link
Hamady, M.; Cheung, Tom Hiu Tung; Resing, K.; Cios, K.J.; Knight, R., Key challenges in proteomics and proteoinformatics, 2005, Link
Hamady, M.; Cheung, Tom Hiu Tung; Tufo, H.; Knight, R., Does protein structure influence trypsin miscleavage?, 2005, Link
Macdonald, M.; Wan, Y.; Wang, W.; Roberts, E.; Cheung, Tom Hiu Tung; Erickson, R.; Knuesel, MT; Liu, X., Control of cell cycle-dependent degradation of c-Ski proto-oncoprotein by Cdc34, 2004, Link
Chen, Fengyuan; Zhou, Jiajian; Li, Yuying; Zhao, Yu; Yuan, Jie; Cao, Yang; Wang, Lijun; Zhang, Zongkang; Zhang, Baoting; Wang, Chi Chiu; Cheung, Tom H.; Wu, Zhenguo; Wong, Carmen Chak‐Lui; Sun, Hao; Wang, Huating, YY1 Regulates Skeletal Muscle Regeneration Through Controlling Metabolic Reprogramming of Satellite Cells, 2019, Link
Knuesel, M.; Cheung, Tom H.; Hamady, M.; Barthel, KKB; Liu, XD, A method of mapping protein sumoylation sites by mass spectrometry using a modified small ubiquitin-like modifier 1 (SUMO-1) and a computational program, 2005, Link
Giordani, Lorenzo; He, Jiawei; Negroni, Elisa; Sakai, Hiroshi; Law, Yiu Chun; Siu, Men Yi Mona; Wan, Raymond; Corneau, Aurélien; Tajbakhsh, Shahragim; Cheung, Hiu Tung; Le grand, Fabien, High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations, 2019, Link
Su, Yiting; Lau, Shun Fat; Ip, P.K. Jacque; Cheung, Kit; Cheung, Hiu Tung; Fu, Kit Yu; Ip, Nancy Yuk-yu, α2-chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis, 2019, Link
Mueller, A.A.; Cheung, Tom Hiu Tung; Rando, T.A., All's well that ends well: Alternative polyadenylation and its implications for stem cell biology, 2013, Link